Müllerian inhibiting substance/anti-Müllerian hormone: A novel treatment for gynecologic tumors
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منابع مشابه
Müllerian inhibiting substance/anti-Müllerian hormone: A novel treatment for gynecologic tumors
Müllerian inhibiting substance (MIS), also called anti-Müllerian hormone (AMH), is a member of the transforming growth factor-β super-family of growth and differentiation response modifiers. It is produced in immature Sertoli cells in male embryos and binds to MIS/AMH receptors in primordial Müllerian ducts to cause regression of female reproductive structures that are the precursors to the fal...
متن کاملThe expression of Müllerian inhibiting substance/anti-Müllerian hormone type II receptor in myoma and adenomyosis
Objective We compared the expression levels of Müllerian inhibiting substance (MIS)/anti-Müllerian hormone type II receptor (AMHRII) in uterine myoma and adenomyosis to evaluate the possibility of using MIS/anti-Müllerian hormone (AMH) as a biological regulator or therapeutic agent in patients with uterine leiomyoma and adenomyosis. Methods We studied normal uterine myometrium, leiomyoma, end...
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Müllerian Inhibiting Substance (MIS) expression is inversely proportional to the serum concentration of testosterone in males after birth and in vitro studies have shown that MIS can lower testosterone production by Leydig cells. Also, mice overexpressing MIS exhibited Leydig cell hypoplasia and lower levels of serum testosterone, but it is not clear whether this is a result of MIS affecting th...
متن کاملAnti-Müllerian hormone profiles as a novel biomarker to diagnose granulosa-theca cell tumors in cattle.
This study was carried out to evaluate the blood profile and tissue expression of Anti-Müllerian hormone (AMH) as a biomarker for granulosa-theca cell tumors (GTCTs) in cattle. Five cases with unilateral ovarian GTCTs (GTCT group) were investigated in comparison to other groups of Japanese Black cows, which had either cystic ovarian disease (COD group, n=5), a functional corpus luteum on Days 9...
متن کاملPersistent Müllerian duct syndrome: A novel mutation in the Αnti-Müllerian Ηormone gene.
BACKGROUND AND OBJECTIVE Persistent Müllerian duct syndrome (PMDS) is a relatively rare form of 46,XY disorder of sex development caused by the failure of formation, release or action of anti-Müllerian hormone (AMH) in intrauterine life. In this report we describe a case diagnosed with PMDS with a novel homozygous mutation in the AMH gene. CASE REPORT A 4-month-old male presented with bilater...
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ژورنال
عنوان ژورنال: Obstetrics & Gynecology Science
سال: 2014
ISSN: 2287-8572,2287-8580
DOI: 10.5468/ogs.2014.57.5.343